It's important to remember that while ARICEPT treats the symptoms of Alzheimer's disease, it is not a cure. All patients will get worse over time, even if they take ARICEPT 23 mg.
Chemical Name: DONEPEZIL (doh-NEP-eh-zil)
Aricept (Donepezil) is used to treat the symptoms of mild to moderate Alzheimer's disease. Donepezil will not cure Alzheimer's disease, and it will not stop the disease from getting worse.
Warnings:
SIDE EFFECTS that may occur while taking this medication includes diarrhea, loss of appetite, muscle cramps, nausea, trouble in sleeping, unusual tiredness or weakness and vomiting.
INDICATION
ARICEPT® (donepezil HCl) is a prescription medicine to treat mild, moderate, and severe Alzheimer's disease.
DOSING INFORMATION
Before starting on ARICEPT 23 mg/day, patients should be on ARICEPT 10 mg/day for at least 3 months. The starting dose of ARICEPT is 5
mg/day and can be increased to 10 mg/day after 4 - 6 weeks. Please take ARICEPT as prescribed by the doctor.
IMPORTANT SAFETY INFORMATION
- ARICEPT is not for everyone, including people who are allergic to any ingredients in ARICEPT or to medicines that contain piperidines.
- Tell the doctor if your loved one takes nonprescription or prescription medicines, including those used to treat Alzheimer's or Parkinson's
disease; anticholinergic medicines, such as allergy or cold medicine; medicines to treat bladder or bowel spasms; or certain asthma medicines.
- ARICEPT may cause slow heartbeat and fainting. This happens more often in people with heart problems. Call the doctor right away if the patient
faints while taking ARICEPT. People may also have seizures while taking ARICEPT. They may also have difficulty passing urine. Lung problems, including asthma,
may worsen with the use of ARICEPT. Tell the doctor that the patient takes ARICEPT before they have any procedure that may require anesthesia, including dental
and medical procedures or surgery.
- People at risk for stomach ulcers or who take certain other medicines, such as aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs), should
tell their doctor because serious stomach problems, such as bleeding, may get worse.
- In a study, more side effects were seen with ARICEPT 23 mg than with ARICEPT 10 mg. Many more people taking ARICEPT 23 mg experienced nausea and
vomiting than those taking ARICEPT 10 mg. These side effects may get better after the patient takes ARICEPT for a while. Other side effects that were seen more
often with ARICEPT 23 mg were stomach ulcers, gastrointestinal bleeding, and weight loss. People of lower weight (less than 121 lbs) may have increased nausea,
vomiting, and weight loss when taking ARICEPT 23 mg.
- Other side effects of ARICEPT may include diarrhea, difficulty sleeping, vomiting, or muscle cramps. Some people may feel tired or may have loss
of appetite.
For Full Prescribing and Patient Information, click here.
The ARICEPT Patient Assistance Program can help qualified indigent and uninsured patients obtain ARICEPT at no cost. To learn more and receive an
application for assistance, please contact us Monday - Friday from 9 AM to 6 PM ET at: Phone: 1-800-226-2072, Fax: 1-800-226-2059.
This site is intended for residents of the United States only. The products discussed herein may have different product labeling in different countries.
ARICEPT® is a registered trademark of Eisai Co., Ltd.
© 2011 Eisai Inc. and Pfizer Inc. All rights reserved. AAR00434
Why is this medication prescribed?
Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) associated with Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, social interaction, reasoning and language abilities, and ability to perform activities of daily living) by increasing the amount of a certain naturally occurring substance in the brain. Donepezil may improve the ability to think and remember or slow the loss of these abilities in people who have AD. However, donepezil will not cure AD or prevent the loss of mental abilities at some time in the future.
How should this medicine be used?
Donepezil comes as a tablet and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It is usually taken once a day, in the evening at bedtime, with or without food. Take donepezil at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. It may take awhile before you experience the full benefits of donepezil. Take donepezil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Donepezil helps control the symptoms of Alzheimer's disease but does not cure it. Continue to take donepezil even if you feel well. Do not stop taking donepezil without talking to your doctor.
Your doctor may start you on a low dose of donepezil and increase your dose after 4 to 6 weeks.
To take the orally disintegrating tablet, place the tablet on your tongue. The tablet will quickly dissolve and can be followed with a drink of water.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking donepezil,
- tell your doctor and pharmacist if you are allergic to donepezil or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines; aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); bethanechol (Duvoid, Urabeth, Urecholine); carbamazepine (Tegretol); dexamethasone (Decadron, Dexone); ipratropium (Atrovent); ketoconazole (Nizoral); medications for glaucoma, irritable bowel disease, motion sickness, myasthenia gravis, Parkinson's disease, ulcers, or urinary problems; phenobarbital (Luminal, Solfoton); phenytoin (Dilantin); quinidine (Quinidex); and rifampin (Rifadin, Rimactane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had gastrointestinal (GI) bleeding; an ulcer,asthma, or obstructive pulmonary disease (chronic bronchitis or emphysema), or heart disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking donepezil, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking donepezil.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose of Aricept (Donepezil)?
If you forget to take a dose of donepezil, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you do not take donepezil, for 1 week or longer, you should call your doctor before starting to take this medication again.
What side effects can this medication cause?
Donepezil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea
- vomiting
- diarrhea
- loss of appetite
- weight loss
- frequent urination
- muscle cramps
- joint pain, swelling, or stiffness
- pain
- excessive tiredness
- drowsiness
- headache
- dizziness
- nervousness
- depression
- confusion
- changes in behavior
- abnormal dreams
- difficulty falling asleep or staying asleep
- discoloration or bruising of the skin
- red, scaling, itchy skin
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- fainting
- slow heartbeat
- chest pain
- black or tarry stools
- red blood in stools
- bloody vomit
- vomit that looks like coffee grounds
- inability to control urination
- difficulty urinating or pain when urinating
- lower back pain
- fever
- seizures
Donepezil may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- nausea
- vomiting
- drooling
- sweating
- slow heartbeat
- difficulty breathing
- muscle weakness
- fainting
- seizures
What other information should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
American Society of Health-System Pharmacists, Disclaimer
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Consumer Medication Information. Copyright, 2011. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
The following brand names are from RxNorm, a standardized nomenclature for clinical drugs produced by the National Library of Medicine:
Brand names
