Temaril-P is used to treat itching and coughing (including kennel cough) in dogs. Temaril-P requires a prescription from your veterinarian, and is sold per tablet.
For: Dogs
| Benefits: |
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Easy to administer |
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Comes in scored tablet to break in half for smaller dogs |
How it works:
Temaril-P contains trimeprazine and prednisolone. Trimeprazine is an antihistamine, which helps relieve itching and coughing. Prednisolone is a corticosteroid that reduces inflammation.
Cautions:
Temaril-P should be given with food to prevent stomach upset. May cause drowsiness. Do not give to pregnant dogs.
Caution
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Action
The exclusive
Temaril-P formula combines the antipruritic and antitussive action of trimeprazine with the anti-inflammatory action of prednisolone. A therapeutic effect is attained by administering the tablets twice daily.
Recommendations For Use
1. Antipruritic: Temaril-P is recommended for the relief of itching regardless of cause. Its usefulness has been demonstrated for the relief of itching and the reduction of inflammation commonly associated with most skin disorders of dogs such as the eczema caused by internal disorders, otitis, and dermatitis (allergic, parasitic, pustular, and nonspecific). It often relieves pruritis which does not respond to other therapy. With any pruritus treatment, the cause should be determined and corrected; otherwise, signs are likely to recur following discontinuance of therapy.
2. Antitussive: Temaril-P has been found to be effective therapy and adjunctive therapy in various cough conditions of dogs. Therefore, in addition to its antipruritic action, Temaril-P is recommended for the treatment of “kennel cough” or tracheobronchitis, bronchitis including all allergic bronchitis and infections and coughs of nonspecific origin. (Coughs due to cardiac insufficiencies would not be expected to respond to Temaril-P therapy.) As with any antitussive treatment, the etiology of the cough should be determined and eliminated if possible. Otherwise, symptoms are likely to recur following discontinuance of therapy.
Note
Temaril-P may be administered to animals suffering from acute or chronic bacterial infections provided the infection is controlled by appropriate antibiotic or chemotherapeutic agents.
Precautions And Side Effects
All the precautions applicable to cortisone and to phenothiazine derivatives apply also to Temaril-P. Possible side effects attributable to corticosteroids include sodium retention and potassium loss, negative nitrogen balance, suppressed adrenal cortical function, delayed wound healing, osteoporosis, elevated levels of SGPT and SAP, and vomiting and diarrhea (occasionally bloody). Cushings syndrome in dogs has been reported in association with prolonged or repeated steroid therapy. Possible increased susceptibility to bacterial invasion and/or the exacerbation of preexisting bacterial infection may occur in patients receiving corticosteroids. As noted above, however, this problem can be avoided by concomitant use of appropriate anti-infective agents. Possible side effects attributable to phenothiazine derivatives include sedation; protruding nictitating membrane; blood dyscrasias; intensification and prolongation of the action of analgesics, sedatives and general anesthetics; and potentiation of organophosphate toxicity and the activity of procaine hydrochloride.
It should be remembered that the premonitory signs of cortisone overdosage, such as sodium retention and edema, may not occur with prednisolone. Therefore, the veterinarians must be alert to detect less obvious side effects, such as blood dyscrasias, polydipsia and polyuria.
The appearance and severity of side effects are dose related and are minimal at the recommended dosage level. If troublesome side effects are encountered, the dosage of Temaril-P should be reduced and discontinued unless the severity of the condition being treated makes its relief paramount.
Prolonged treatment with Temaril-P must be withdrawn gradually. Use of corticosteroids, depending on dose, duration, and specific steroid, may result in inhibition of endogenous steroid production following drug withdrawal. In patients presently receiving or recently withdrawn from systemic steroid treatments, therapy with a rapidly acting corticosteroid should be considered in unusually stressful situations.
Warning
Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Corticosteroids administered to dogs during pregnancy have also resulted in other congenital anomalies, including deformed forelegs, phocomelia, and anasarca. If a vasoconstrictor is needed, norepinephrine should be used in lieu of epinephrine. Phenothiazine derivatives may reverse the usual elevating action of epinephrine causing further lowering of blood pressure.
Recommended Dosage
The same dosage schedule may be followed for both antipruritic and antitussive therapy.
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Weight of Dog
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Initial Dosage
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Up to 10 lb
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1/2 tablet, twice daily
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11-20 lb
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1 tablet, twice daily
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21-40 lb
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2 tablets, twice daily
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Over 40 lb
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3 tablets, twice daily
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After 4 days, reduce dosage to 1/2 of the initial dose or to an amount just sufficient to maintain remission of symptoms. Individual animal response will vary and dosage should be adjusted until proper response is obtained.
Store in a Dry, Cool Place at Temperatures Not Above 25°C (77°F)
How Supplied
100- and 1000-tablet bottles.
References
1. Knowles JO, Knowles RP: Preliminary reports on an effective antipruritic agent. Vet Med 55(8):67-68, 1960.
2. Candlin FT: An agent to aid in control of pruritus, Vet Med 56(5):207-208, 1961.
3. Yoxall AT, Hird JRF: Pharmacological Basis of Small Animal Medicine . Blackwell Scientific Publications, London, pp. 99-102, 1979.
4. Booth N, McDonald LE: Veterinary Pharmacology and Therapeutics, 5th ed. Iowa State University Press, Ames, pp. 564-570, 1982.
5. Davis L: Handbook of Small Animal Therapeutics . Churchill Livingstone, New York, pp. 140-142; 459-461; 468-469, 1985.
6. Scott D: Systemic glucocorticoid therapy. Current Veterinary Therapy, Kirk WV Saunders, ed., Philadelphia, pp. 988-994, 1980.
7. Lecture: "Rational Steroid Therapy" Duncan C. Ferguson, VMD, PhD, Department of Pharmacology, Cornell University.
8. Kemppianen RJ, Lorenz MD, Thompson FN: Adrenocortical suppression in the dog given a single intramuscular dose of prednisolone or triamcinolone acetonide. Am J Vet Res 42(2):204-206, 1982.
9. Rogers WA, Ruebner BH: A retrospective study of probable glucocorticoid induced hepatopathy in dogs. JAVMA 170(6).
U.S. Patent No. 2,837,518
Licensed under U.S. Patent No. 3,134,718
NADA # 12-437, Approved by FDA
Distributed by: Pfizer Animal Health, Exton, PA 19341, USA
Div. of Pfizer Inc, NY, NY 10017
75-8548-09
January 2001
Nac No.
36901441
PFIZER INC.
PFIZER ANIMAL HEALTH
235 E. 42ND ST., NEW YORK, NY, 10017
| Telephone: |
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269-833-4000 |
| Customer Service: |
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800-733-5500 and 800-793-0596 |
| Veterinary Medical Investigations & Product Support: |
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800-366-5288 |
| Technical Services (USA): |
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800-366-5288 |
| Website: |
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http://pfizerah.com |
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Every effort has been made to ensure the accuracy of the Temaril-P Tablets information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. |
More Information:
Brand Name
Temaril-P (Pfizer Animal Health)
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Generic Name
Trimeprazine with prednisolone (tri-mep?-rah-zeen) |
What is the most important information I should know about Temaril-P:
Temaril-P is a prescription medication that is FDA approved for use in dogs. Temaril-P is available as a scored tablet containing trimeprazine tartrate equivalent to 5mg trimeprazine and prednisolone 2mg. Prolonged use of Temaril-P should not be stopped suddenly. There should be a gradual reduction in dosage before stopping. Temaril-P should be taken with food to lessen stomach upset.
What is Temaril-P:
Temaril-P is a combination antihistamine (trimeprazine) and corticosteroid (prednisone). Temaril-P is used for the relief of itching regardless of cause. It is also used in the treatment of various cough conditions such as kennel cough, bronchitis and coughs of nonspecific origin. Temaril-P may also be used for purposes other than those listed in this guide.
What should I discuss with my veterinarian before giving Temaril-P to my pet:
Do not give Temaril-P to your pet if the pet has a serious viral or fungal infection. Temaril-P can be given in the presence of acute or chronic bacterial infections provided the infection is controlled by antibiotic. Temaril-P may weaken the pet¿s immune response and its ability to fight infections. Tell your veterinarian if your pet has diabetes mellitus or any other medical conditions. Tell your veterinarian if your pet is being giv en phenytoin, Phenobarbital, diuretics, or insulin. Also tell your veterinarian if the pet is pregnant or lactating.
How should this medication be given:
Give this medication exactly as directed by your veterinarian. Do not give more or less than is prescribed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. The usual dose of Temaril-P is based on weight. For dogs up to 10 lbs gibe 1/2 tablet, for 11-20 lbs give 1 tablet, 21-40 lbs give 2 tablets and 41 lbs and up give 3 tablets. These tablets are given twice a day. After 4 days, the dose is typically reduced to 1/2 the initial dose. Keep plenty of water available for the pet. Temaril-P should be given with food. Store Temaril-P at room temperature away from moisture and heat. Keep this medication away from children and pets.
What happens if I miss giving a dose:
Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.
What happens if I overdose the pet:
Seek emergency veterinary medical treatment. Symptoms of overdose may include excess drowsiness, low blood pressure, and seizures.
What should I avoid while giving Temaril-P to my pet:
Do not give Temaril-P to dogs allergic to it or to either of its ingredients. Temaril-P should not be given to dogs that are pregnant or that are diabetic. Temaril-P may cause drowsiness. Do not use any vaccines without checking with the veterinarian.
What are the possible side effects of Temaril-P:
If any of the following serious side effects occur, stop giving Temaril-P and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives). Trimeprazine can cause drowsiness, tremors and muscle weakness. Prednisolone may cause symptoms of Cushing¿s disease which include increased thirst, urination and hunger as well as vomiting and diarrhea. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
What other drugs will affect Temaril-P:
Do not give any other over the counter or prescription medications, including herbal products, during treatment with Temaril-P without first talking to the veterinarian. Many other medications can interact with Temaril-P resulting in side effects or altered effectiveness. These include sedatives, anesthetics, pain medications, epinephrine and procaine.
Where can I get more information:
Your pharmacist has additional information about Temaril-P written for health professionals that you may read. |
Directions:
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Temaril-P is a combination of an antihistamine (trimeprazine) and a corticosteroid (prednisolone) available by prescription for use in dogs. |
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Temaril-P is used for the relief of itching regardless of cause. It is also used in the treatment of various cough conditions such as kennel cough, bronchitis, and coughs of nonspecific origin. |
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Allow plenty of water for the pet to drink. |
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Tip: Prolonged use of Temaril-P should not be stopped suddenly. There should be a gradual reduction in dosage before stopping.
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| Dosage: |
| Pet |
Weight |
Dosage |
| Dogs: |
Up to 10 lbs |
Initially, give ½ tablet twice daily with food to lessen stomach upset. After 4 days, the dose is typically reduced to ½ of the initial dose |
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11-20 lbs |
Initially, give 1 tablet twice a day with food to lessen stomach upset. After 4 days, the dose is typically reduced to ½ of the initial dose |
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21-40 lbs |
Initially, give 2 tablets twice a day with food to lessen stomach upset. After 4 days, the dose is typically reduced to ½ of the initial dose |
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Over 40 lbs |
Initially, give 3 tablets twice a day with food to lessen stomach upset. After 4 days, the dose is typically reduced to ½ of the initial dose |
| Cats/Kittens: |
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| Horses: |
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| Storage: Store Temaril-P at room temperature away from moisture and heat. |
| Active Ingredient (per tablet) |
Amount |
| Trimeprazine Tartrate |
5 mg |
| Prednisolone |
2 mg |
